植物分类学报    2008 46 (3): 405-423    ISSN: 0529-1526  CN: 11-1897/Q  首页     当期目录 上一期    下一期

 
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· 马红

真核生物SMC基因家族中拷贝数目的长期稳定进化

1 4Alexandra SURCEL, 1 2Xiaofan ZHOU*, 2 3Li QUAN, 1 2马红*

1(The Intercollege Graduate Program in Cell and Developmental Biology, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA)
2(Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA)
3(The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA)
4(Present address: Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA)

收稿日期 2008-3-5   修回日期 2008-4-23   网络版发布日期  2008-5-9   接受日期 
摘要  Members of the Structural Maintenance of Chromosome (SMC) family have long been of interest to molecular and evolutionary biologists for their role in chromosome structural dynamics, particularly sister chromatid cohesion, condensation, and DNA repair. SMC and related proteins are found in all major groups of living organisms and share a common structure of conserved N and C globular domains separated from the conserved hinge domain by long coiled-coil regions. In eukaryotes there are six paralogous proteins that form three het-erodimeric pairs, whereas in prokaryotes there is only one SMC protein that homodimerizes. From recently com-pleted genome sequences, we have identified SMC genes from 34 eukaryotes that have not been described in previous reports. Our phylogenetic analysis of these and previously identified SMC genes supports an origin for the vertebrate meiotic SMC1 in the most recent common ancestor since the divergence from invertebrate animals. Additionally, we have identified duplicate copies due to segmental duplications for some of the SMC paralogs in plants and yeast, mainly SMC2 and SMC6, and detected evidence that duplicates of other paralogs were lost, suggesting differential evolution for these genes. Our analysis indicates that the SMC paralogs have been stably maintained at very low copy numbers, even after segmental (genome-wide) duplications. It is possible that such low copy numbers might be selected during eukaryotic evolution, although other possibilities are not ruled out.

关键词
   cohesin   condensin   meiosis   segmental duplication   SMC  
分类号
DOI:  10.3724/SP.J.1002.2008.08031
 

通讯作者:
马红hd hxm16@psu.edu 桠
作者个人主页: 1 4Alexandra SURCEL; 1 2Xiaofan ZHOU*; 2 3Li QUAN; 1 2马红*